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We retrospectively examined the clinical courses of 20 children with severe near-drowning and divided their outcomes into 3 groups:normal(4), persistent vegetative state(9),and dead(7).We reviewed serial blood glucose levels and cerebral blood flow measured by stable xenon computed tomography within the 1st 48 hours of admission to determine whether they were predictive of outcome.Total,frontal gray,frontal white,and temporal and parietal gray matter cerebral blood flows were significantly decreased in children who died compared with those who completely recovered.Only 1/2 the children surviving in a vegetative state had decreased flows compared with those who recovered.An elevated initial blood glucose was highly predictive of those patients who died(mean,511+/=110 mg%)or those with vegetative survival(465+/=104 mg%)compared with those who recovered completely(238+/=170 mg%).The predictive value of initial blood glucose alone(68%)or CBF alone(50%)was similar to that of clinical rating scales or immersion/resuscitation times.The combination of blood glucose with CBF improved predictability to 79%.Our results that CBF measurements are predictive of eventual death but cannot differentiate normal from vegetative survival.Combining multiple laboratory studies may be of value in predetermining the eventual outcome in near-drowning. |
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